In the 1970s, as the modern obesity epidemic was just getting started, investigators were searching for new animal models of diet-induced obesity. They tried all sorts of things, from sugar to various types of fats, but none of them caused obesity as rapidly and reproducibly as desired*. 1976, Anthony Sclafani tried something new, and disarmingly simple, which he called the "supermarket diet": he gave his rats access to a variety of palatable human foods, in addition to standard rodent chow. They immediately ignored the chow, instead gorging on the palatable food and rapidly becoming obese (
1). Later renamed the "cafeteria diet", it remains the most rapid and effective way of producing dietary obesity and metabolic syndrome in rodents using solid food (
2).
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